Eph receptor B4 (EPHB4) (NM_004444) Human Recombinant Protein

• Background:

  Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene binds to ephrin-B2 and plays an essential role in vascular development. [provided by RefSeq, Jul 2008]

• Synonyms:

  CMAVM2; HFASD; HTK; LMPHM7; MYK1; TYRO11

• Gene ID:

  2050

• UniProt:

  P54760, Q96L35, Q541P7

• Accession Number mRNA:

  NM_004444

• Chromosomal Location:

  7q22.1

• Expression System:

  Sf9

• Tag:

  C-DDK

• Related Pathways:

  Axon guidance

• Field of Research:

  Axon guidance

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  50mM Tris-HCl, pH8.0, 100mM glycine, 10% glycerol.

• Function:

  Druggable Genome, Protein Kinase, Transmembrane

• Molecular Weight:

  57 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  EPHB4

• Species:

  Human

• Protein ID:

  NP_004435

• Overview:

  Purified recombinant protein of Human EPH receptor B4 (EPHB4), residues 16-539aa, with C-terminal DDK tag, expressed in sf9, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/2050

• Uniprot URL:

  https://www.uniprot.org/uniprot/P54760

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_004444

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_004435