ATF 4 (ATF4) (NM_001675) Human Recombinant Protein

• Background:

  This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2) . The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication. [provided by RefSeq, Sep 2011]

• Synonyms:

  CREB-2; CREB2; TAXREB67; TXREB

• Gene ID:

  468

• UniProt:

  P18848

• Accession Number mRNA:

  NM_001675

• Chromosomal Location:

  22q13.1

• Expression System:

  E. coli

• Tag:

  N-His

• Related Pathways:

  GnRH signaling pathway, Long-term potentiation, MAPK signaling pathway, Neurotrophin signaling pathway, Prostate cancer

• Field of Research:

  GnRH signaling pathway, Long-term potentiation, MAPK signaling pathway, Neurotrophin signaling pathway, Prostate cancer

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl

• Function:

  Transcription Factors

• Molecular Weight:

  38.4 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  ATF4

• Species:

  Human

• Protein ID:

  NP_001666

• Overview:

  Purified recombinant protein of Human activating transcription factor 4 (tax-responsive enhancer element B67) (ATF4), transcript variant 1, full length, with N-terminal HIS tag, expressed in E.Coli, 50ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/468

• Uniprot URL:

  https://www.uniprot.org/uniprot/P18848

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_001675

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_001666