ATF 4 (ATF4) Mouse Monoclonal Antibody [Clone ID: LBI5F5]

• Background:

  This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2) . The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication. [provided by RefSeq, Sep 2011].

• Synonyms:

  CREB-2; CREB2; TAXREB67; TXREB

• Gene Name:

  Homo sapiens activating transcription factor 4 (ATF4), transcript variant 1, mRNA.

• Gene ID:

  468

• UniProt:

  P18848

• Conjugation:

  Unconjugated

• Related Pathways:

  GnRH signaling pathway, Long-term potentiation, MAPK signaling pathway, Neurotrophin signaling pathway, Prostate cancer

• Field of Research:

  GnRH signaling pathway, Long-term potentiation, MAPK signaling pathway, Neurotrophin signaling pathway, Prostate cancer

• Dilution:

  WB 1:500

• Form:

  Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

• Buffer:

  Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

• Function:

  Transcription Factors

• Storage Conditions:

  Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

• Symbol:

  ATF4

• Overview:

  Carrier-free (BSA/glycerol-free) ATF4 mouse monoclonal antibody, clone LBI5F5

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=468

• Uniprot URL:

  https://www.uniprot.org/uniprot/P18848