RUNX3 (NM_001031680) Human Recombinant Protein

• Background:

  This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

• Synonyms:

  AML2; CBFA3; PEBP2aC

• Gene ID:

  864

• UniProt:

  Q13761, A0A024RAH4

• Accession Number mRNA:

  NM_001031680

• Chromosomal Location:

  1p36.11

• Expression System:

  E. coli

• Tag:

  N-His

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  50mM Tris, 8M Urea, pH8.0.

• Function:

  Transcription Factors

• Molecular Weight:

  45.7 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  RUNX3

• Species:

  Human

• Protein ID:

  NP_001026850

• Overview:

  Purified recombinant protein of Human runt-related transcription factor 3 (RUNX3), transcript variant 1, full length, with N-terminal HIS tag, expressed in E.Coli, 50ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/864

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q13761

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_001031680

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_001026850