DOK4 (NM_018110) Human Recombinant Protein

• Background:

  DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK4 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway (By similarity) . Putative link with downstream effectors of RET in neuronal differentiation. May be involved in the regulation of the immune response induced by T-cells.[UniProtKB/Swiss-Prot Function]

• Synonyms:

  IRS-5; IRS5

• Gene ID:

  55715

• UniProt:

  Q8TEW6, A0A024R6S2

• Accession Number mRNA:

  NM_018110

• Chromosomal Location:

  16q21

• Expression System:

  E. coli

• Tag:

  N-His

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  50mM Tris, 8M Urea, pH8.0

• Function:

  Druggable Genome

• Molecular Weight:

  36.8 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  DOK4

• Species:

  Human

• Protein ID:

  NP_060580

• Overview:

  Purified recombinant protein of Human docking protein 4 (DOK4), full length, with N-terminal HIS tag, expressed in E. coli, 50ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/55715

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q8TEW6

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_018110

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_060580