C1QA (NM_015991) Human Recombinant Protein

• Background:

  This gene encodes the A-chain polypeptide of serum complement subcomponent C1q, which associates with C1r and C1s to yield the first component of the serum complement system. C1q deficiency is associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains which include 6 A-chains, 6 B-chains, and 6 C-chains. Each chain contains an N-terminal collagen-like region and a C-terminal C1q globular domain. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]

• Synonyms:

  Complement component 1, q subcomponent, A chain; complement component 1, q subcomponent, alpha polypeptide; complement component C1q, A chain; OTTHUMP00000002936

• Gene ID:

  712

• UniProt:

  P02745, A0A024RAG6

• Accession Number mRNA:

  NM_015991

• Chromosomal Location:

  1p36.12

• Expression System:

  E. coli

• Tag:

  N-His

• Related Pathways:

  Complement and coagulation cascades, Prion diseases, Systemic lupus erythematosus

• Field of Research:

  Complement and coagulation cascades, Prion diseases, Systemic lupus erythematosus

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  50mM Tris, 8M Urea, pH8.0.

• Function:

  Secreted Protein

• Molecular Weight:

  25.8 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  C1QA

• Species:

  Human

• Protein ID:

  NP_057075

• Overview:

  Purified recombinant protein of Human complement component 1, q subcomponent, A chain (C1QA), full length, with N-terminal HIS tag, expressed in E. coli, 50ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/712

• Uniprot URL:

  https://www.uniprot.org/uniprot/P02745

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_015991

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_057075