ALS2 (NM_001135745) Human Recombinant Protein

• Background:

  The protein encoded by this gene contains an ATS1/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5. The protein localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics. Mutations in this gene result in several forms of juvenile lateral sclerosis and infantile-onset ascending spastic paralysis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

• Synonyms:

  ALS2CR6; ALSJ; IAHSP; PLSJ

• Gene ID:

  57679

• UniProt:

  Q96Q42

• Accession Number mRNA:

  NM_001135745

• Chromosomal Location:

  2q33.1

• Expression System:

  E. coli

• Tag:

  N-His

• Related Pathways:

  Amyotrophic lateral sclerosis (ALS)

• Field of Research:

  Amyotrophic lateral sclerosis (ALS)

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  50mM Tris, 8M Urea, pH8.0.

• Function:

  Druggable Genome

• Molecular Weight:

  42.4 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  ALS2

• Species:

  Human

• Protein ID:

  NP_001129217

• Overview:

  Purified recombinant protein of Human amyotrophic lateral sclerosis 2 (juvenile) (ALS2), transcript variant 2, full length, with N-terminal HIS tag, expressed in E. coli, 50ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/57679

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q96Q42

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_001135745

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_001129217