TRAF4 (NM_004295) Human Recombinant Protein

• Background:

  This gene encodes a member of the TNF receptor associated factor (TRAF) family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. The encoded protein has been shown to interact with neurotrophin receptor, p75 (NTR/NTSR1), and negatively regulate NTR induced cell death and NF-kappa B activation. This protein has been found to bind to p47phox, a cytosolic regulatory factor included in a multi-protein complex known as NAD (P) H oxidase. This protein thus, is thought to be involved in the oxidative activation of MAPK8/JNK. Alternatively spliced transcript variants have been observed but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]

• Synonyms:

  CART1; MLN62; RNF83

• Gene ID:

  9618

• UniProt:

  Q9BUZ4, A0A024QZ59

• Accession Number mRNA:

  NM_004295

• Chromosomal Location:

  17q11.2

• Expression System:

  E. coli

• Tag:

  N-GST and C-His

• Related Pathways:

  Pathways in cancer, Small cell lung cancer

• Field of Research:

  Pathways in cancer, Small cell lung cancer

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25mM Tris, pH8.0, 150mM NaCl, 10% glycerol, 1%Sarkosyl.

• Function:

  Druggable Genome

• Molecular Weight:

  81.4 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  TRAF4

• Species:

  Human

• Protein ID:

  NP_004286

• Overview:

  Purified recombinant protein of Human TNF receptor-associated factor 4 (TRAF4), full length, with N-terminal GST and C-terminal His tag, expressed in E. coli, 50ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/9618

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9BUZ4

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_004295

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_004286