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AARS Rabbit pAb (APR30124N)

CAT: 0882-APR30124N-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0882-APR30124N-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The human alanyl-tRNA synthetase (AARS) belongs to a family of tRNA synthases, of the class II enzymes. Class II tRNA synthases evolved early in evolution and are highly conserved. This is reflected by the fact that 498 of the 968-residue polypeptide human AARS shares 41% identity witht the E.coli protein. tRNA synthases are the enzymes that interpret the RNA code and attach specific aminoacids to the tRNAs that contain the cognate trinucleotide anticodons. They consist of a catalytic domain which interacts with the amino acid acceptor-T psi C helix of the tRNA, and a second domain which interacts with the rest of the tRNA structure.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality AARS Rabbit pAb (APR30124N) .
Synonyms
AARS; CMT2N; EIEE29
Gene ID
16
UniProt
P49588
Cellular Locus
Cytoplasm
Dilution
WB 1:500 - 1:2000 IHC 1:50 - 1:100
Form
Liquid
Buffer
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Molecular Weight
Calculated MW: 106kDa/109kDa Observed MW: 107kDa
Storage Conditions
Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Gene ID URL
https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=16
Uniprot URL
https://www.uniprot.org/uniprot/P49588
AA Sequence
Email for sequence

UniProtKB · P49588

Alanine--tRNA ligase, cytoplasmic

SYAC_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P49588
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
AARS1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
6.1.1.7
Processing
—
Secondary accessions
A6NF14, B4DR45, Q53GV7, Q96FA0
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationMethylationPhosphoproteinUbl conjugation

Coding sequence diversity

Alternative splicing

Molecular function

Aminoacyl-tRNA synthetaseLigaseRNA-bindingtRNA-binding

Ligand

ATP-bindingMetal-bindingNucleotide-bindingZinc

Disease

Charcot-Marie-Tooth diseaseDisease variantEpilepsyNeurodegenerationNeuropathy

Cellular component

CytoplasmNucleus

Biological process

Protein biosynthesis

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