PER2 Rabbit pAb (APR29926N)

CAT: 0882-APR29926N-01Size: 50 µLDry Ice: NoHazardous: No

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CAT#:0882-APR29926N-01Size:50 µL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene may increase the risk of getting certain cancers and have been linked to sleep disorders.

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality PER2 Rabbit pAb (APR29926N) .

Synonyms

PER2; FASPS; FASPS1

Gene ID

8864

UniProt

O15055

Cellular Locus

Cytoplasm, Nucleus, nucleolus, perinuclear region

Dilution

WB 1:500 - 1:2000

Form

Liquid

Buffer

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Molecular Weight

Calculated MW: 45kDa/136kDa Observed MW: 136kDa

Storage Conditions

Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Gene ID URL

https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8864

Uniprot URL

https://www.uniprot.org/uniprot/O15055

AA Sequence

MNGYAEFPPSPSNPTKEPVEPQPSQVPLQEDVDMSSGSSGHETNENCSTGRDSQGSDCDDSGKELGMLVEPPDARQSPDTFSLMMAKSEHNPSTSGCSSD

UniProtKB · O15055

Period circadian protein homolog 2

PER2_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: O15055
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: PER2
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: hPER2
EC number: —
Processing: —
Secondary accessions: A2I2P7, Q4ZG49, Q6DT41, Q9UQ45

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationPhosphoproteinUbl conjugation

Coding sequence diversity

Alternative splicing

Biological process

Biological rhythmsTranscriptionTranscription regulation

Cellular component

CytoplasmNucleus

Disease

Disease variant

Domain

Repeat

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