SRGAP2 Rabbit pAb (APR29567N)

CAT: 0882-APR29567N-01Size: 50 µLDry Ice: NoHazardous: No

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CAT#:0882-APR29567N-01Size:50 µL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

This locus encodes a member of the SLIT-ROBO Rho GTPase activating protein family. The encoded protein stimulates GTPase activity of Rac1, and plays a role in cortical neuron development. This locus has several paralogs on human chromosome 1 resulting from segmental duplication. While this locus itself is conserved among various species, the paralogs are found only in the genus Homo, and not in the genomes of non-human great apes. Alternatively spliced transcript variants have been described for this locus.

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality SRGAP2 Rabbit pAb (APR24491N2) .

Synonyms

SRGAP2; ARHGAP34; FNBP2; SRGAP2A; SRGAP3

Gene ID

23380

UniProt

O75044

Cellular Locus

Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoplasmic vesicle, Nucleus, dendritic spine, lamellipodium, phagosome, postsynaptic cell membrane, postsynaptic density, synapse

Dilution

WB 1:500 - 1:1000

Form

Liquid

Buffer

Buffer: PBS with 0.02% sodium azide, pH7.3.

Molecular Weight

Calculated MW: 120kDa Observed MW: 140KDa

Storage Conditions

Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Gene ID URL

https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=23380

Uniprot URL

https://www.uniprot.org/uniprot/O75044

AA Sequence

Email for sequence

UniProtKB · O75044

SLIT-ROBO Rho GTPase-activating protein 2

SRGP2_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: O75044
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: SRGAP2
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: srGAP2
EC number: —
Processing: —
Secondary accessions: A2RUF3

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Cellular component

Cell membraneCell projectionCytoplasmCytoplasmic vesicleMembraneNucleusPostsynaptic cell membraneSynapse

Coding sequence diversity

Chromosomal rearrangement

Domain

Coiled coilSH3 domain

Molecular function

GTPase activation

PTM

MethylationPhosphoprotein

Biological process

Neurogenesis

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