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HLA-E Rabbit pAb (APR28216N)

CAT: 0882-APR28216N-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0882-APR28216N-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin) . The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality HLA-E Rabbit pAb (APR28216N) .
Synonyms
HLA-6.2; QA1; HLA-E; EA1.2; EA2.1
Gene ID
3133
UniProt
P13747
Cellular Locus
Membrane, Single-pass type I membrane protein
Applications
WB (Mus musculus)
Dilution
WB 1:500 - 1:2000
Form
Liquid
Buffer
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Molecular Weight
Calculated MW: 40kDa Observed MW: 45kDa
Storage Conditions
Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Gene ID URL
https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3133
Uniprot URL
https://www.uniprot.org/uniprot/P13747
AA Sequence
MVDGTLLLLLSEALALTQTWAGSHSLKYFHTSVSRPGRGEPRFISVGYVDDTQFVRFDNDAASPRMVPRAPWMEQEGSEYWDRETRSARDTAQIFRVNLR

UniProtKB · P13747

HLA class I histocompatibility antigen, alpha chain E

HLAE_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P13747
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
HLA-E
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
E2G051, Q30169, Q6DU44, Q9BT83, Q9GIY7, Q9GIY8
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Biological process

Adaptive immunityHost-virus interactionImmunityInnate immunity

Cellular component

Cell membraneGolgi apparatusMembraneMHC ISecreted

PTM

Disulfide bondGlycoproteinPhosphoprotein

Domain

SignalTransmembraneTransmembrane helix

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