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[KO Validated] TLK2 Rabbit pAb (APR26833N)

CAT: 0882-APR26833N-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0882-APR26833N-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a nuclear serine/threonine kinase that was first identified in Arabidopsis. The encoded protein is thought to function in the regulation of chromatin assembly in the S phase of the cell cycle by regulating the levels of a histone H3/H4 chaperone. This protein is associated with double-strand break repair of DNA damage caused by radiation. Pseudogenes of this gene are present on chromosomes 10 and 17. Alternate splicing results in multiple transcript variants.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality [KO Validated] TLK2 Rabbit pAb (APR26833N) .
Synonyms
TLK2; HsHPK; PKU-ALPHA
Gene ID
11011
UniProt
Q86UE8
Cellular Locus
Cytoplasm, Nucleus, cytoskeleton, perinuclear region
Dilution
WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:100
Form
Liquid
Buffer
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Molecular Weight
Calculated MW: 82kDa/85kDa/87kDa Observed MW: 87kDa
Storage Conditions
Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Gene ID URL
https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=11011
Uniprot URL
https://www.uniprot.org/uniprot/Q86UE8
AA Sequence
MMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPLPRRVEQPLYGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQNSPSSTGSGNTEHSCSSQKQISIQHRQTQSDLTIEKISAL

UniProtKB · Q86UE8

Serine/threonine-protein kinase tousled-like 2

TLK2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q86UE8
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
TLK2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.7.11.1
Processing
—
Secondary accessions
D3DU07, Q9UKI7, Q9Y4F7
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingNucleotide-binding

Biological process

Cell cycleDNA damage

Molecular function

Chromatin regulatorKinaseSerine/threonine-protein kinaseTransferase

Domain

Coiled coil

Cellular component

CytoplasmCytoskeletonNucleus

Disease

Disease variantIntellectual disability

PTM

Phosphoprotein

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