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BAP1 Rabbit pAb (APR26610N)

CAT: 0882-APR26610N-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0882-APR26610N-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene belongs to the ubiquitin C-terminal hydrolase subfamily of deubiquitinating enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germline mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, uveal melanoma and cutaneous melanoma.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality BAP1 Rabbit pAb (APR26610N) .
Synonyms
BAP1; HUCEP-13; UCHL2; hucep-6
Gene ID
8314
UniProt
Q92560
Cellular Locus
Cytoplasm, Nucleus
Applications
WB (NCI-N87 cells)
Dilution
WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Form
Liquid
Buffer
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Molecular Weight
Calculated MW: 80kDa Observed MW: 95KDa
Storage Conditions
Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Gene ID URL
https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8314
Uniprot URL
https://www.uniprot.org/uniprot/Q92560
AA Sequence
SIPLSIKTSSGAGSPAVAVPTHSQPSPTPSNESTDTASEIGSAFNSPLRSPIRSANPTRPSSPVTSHISKVLFGEDDSLLRVDCIRYNRAVRDLGPVISTGLLHLAEDGVLSPLALTEGGKGSSPSIRPIQGSQGSSSPVEKEVVEATDSREKTGMVRPGEPLSGEKYSPKELLALLKCVEAEIANYEACLKEEVEKRKKFKIDDQRRTHNYDEFICTFISMLAQEGMLANLVEQNISVRRRQGVSIGRLHKQRKPDRRKRSRPYKAKRQ

UniProtKB · Q92560

Ubiquitin carboxyl-terminal hydrolase BAP1

BAP1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q92560
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
BAP1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.4.19.12
Processing
—
Secondary accessions
A8K993, Q6LEM0, Q7Z5E8
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Molecular function

Chromatin regulatorDevelopmental proteinHydrolaseProteaseThiol protease

Cellular component

ChromosomeCytoplasmNucleus

Domain

Coiled coil

Biological process

DifferentiationUbl conjugation pathway

Disease

Disease variantIntellectual disability

PTM

PhosphoproteinUbl conjugation

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