BRCA2 Rabbit pAb (APR24770N)

CAT: 0882-APR24770N-01Size: 50 µLDry Ice: NoHazardous: No

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CAT#:0882-APR24770N-01Size:50 µL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele.

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality BRCA2 Rabbit pAb (APR24770N) .

Synonyms

BRCA2; BRCC2; BROVCA2; FACD; FAD; FAD1; FANCD; FANCD1; GLM3; PNCA2; XRCC11

Gene ID

675

UniProt

P51587

Cellular Locus

Cytoplasm, Nucleus, centrosome, cytoskeleton, microtubule organizing center

Applications

IF (Oryza sativa)

Dilution

WB 1:500 - 1:2000 IF 1:50 - 1:200

Form

Liquid

Buffer

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Molecular Weight

Calculated MW: 384kDa Observed MW: 384kDa

Storage Conditions

Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Gene ID URL

https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=675

Uniprot URL

https://www.uniprot.org/uniprot/P51587

AA Sequence

MPIGSKERPTFFEIFKTRCNKADLGPISLNWFEELSSEAPPYNSEPAEESEHKNNNYEPNLFKTPQRKPSYNQLASTPIIFKEQGLTLPLYQSPVKELDKFKLDLGRNVPNSRHKSLRTVKTKMDQADDVSCPLLNSCLSESPVVLQCTHVTPQRDKSVVCGSLFHTPKFVKGRQTPKHISESLGAEVDPDMSWSSSLATPPTLSSTVLIVRNEEASETVFPHDTTANVKSYFSNHDESLKKNDRFIASVTDSENTNQREAASHGFGKTSGNSFKVNSCKDHIGKSMPNVLEDEVYETVV

UniProtKB · P51587

Breast cancer type 2 susceptibility protein

BRCA2_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P51587
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: BRCA2
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: —
Secondary accessions: O00183, O15008, Q13879, Q5TBJ7

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Biological process

Cell cycleDNA damageDNA recombinationDNA repairMeiosis

Cellular component

ChromosomeCytoplasmCytoskeletonNucleusTelomere

Disease

Disease variantFanconi anemiaTumor suppressor

Molecular function

DNA-binding

PTM

PhosphoproteinUbl conjugation

Domain

Repeat

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