STAT4 Rabbit pAb (APR24893N)

CAT: 0882-APR24893N-01Size: 50 µLDry Ice: NoHazardous: No

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CAT#:0882-APR24893N-01Size:50 µL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein.

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality STAT4 Rabbit pAb (APR24893N) .

Synonyms

STAT4; SLEB11

Gene ID

6775

UniProt

Q14765

Cellular Locus

Cytoplasm, Nucleus

Dilution

WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200

Form

Liquid

Buffer

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Molecular Weight

Calculated MW: 85kDa Observed MW: 93kDa

Storage Conditions

Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Gene ID URL

https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6775

Uniprot URL

https://www.uniprot.org/uniprot/Q14765

AA Sequence

SESHLGGITFTWVDHSESGEVRFHSVEPYNKGRLSALPFADILRDYKVIMAENIPENPLKYLYPDIPKDKAFGKHYSSQPCEVSRPTERGDKGYVPSVFIP

UniProtKB · Q14765

Signal transducer and activator of transcription 4

STAT4_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: Q14765
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: STAT4
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: —
Secondary accessions: Q96NZ6

Protein keywords

PTM

AcetylationPhosphoprotein

Molecular function

ActivatorDNA-binding

Cellular component

CytoplasmNucleus

Disease

Disease variantSystemic lupus erythematosus

Technical term

Proteomics identificationReference proteome

Domain

SH2 domain

Biological process

TranscriptionTranscription regulation

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Alternative Products

Catalog	Name
MBS8542884-01	STAT4 Rabbit pAb
MBS9470012-01	STAT4 Rabbit mAb