ARHGAP11B Rabbit pAb (APR23188N)

CAT: 0882-APR23188N-01Size: 50 µLDry Ice: NoHazardous: No

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CAT#:0882-APR23188N-01Size:50 µL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

Hominin-specific protein that promotes development and evolutionary expansion of the brain neocortex. Able to promote amplification of basal progenitors in the subventricular zone, producing more neurons during fetal corticogenesis, thereby playing a key role in neocortex expansion. Promotes the proliferation of basal progenitors by inhibiting the mitochondrial permeability transition pore (mPTP: delays the opening of the mPTP via interaction with ADP:ATP translocase, thereby increasing mitochondrial Ca (2+ concentration and inducing glutamine catabolism, which is required for basal progenitor proliferation. Does not possess GTPase activator activity: the absence of GTPase activator activity is required to promote amplification of basal progenitors during neocortex development.

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality ARHGAP11B Rabbit pAb (APR23188N) .

Synonyms

ARHGAP11B; FAM7B1

Gene ID

89839

UniProt

Q3KRB8

Dilution

WB 1:500 - 1:2000

Form

Liquid

Buffer

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Molecular Weight

Calculated MW: 30kDa Observed MW: 30kDa

Storage Conditions

Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Gene ID URL

https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=89839

Uniprot URL

https://www.uniprot.org/uniprot/Q3KRB8

AA Sequence

EKKGVYQTLSWKRYQPCWVLMVSVLLHHWKALKKVNMKLLVNIREREDNV

UniProtKB · Q3KRB8

Inactive Rho GTPase-activating protein 11B

RHGBB_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: Q3KRB8
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: ARHGAP11B
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: Precursor
Secondary accessions: —

Protein keywords

Molecular function

GTPase activation

Cellular component

Mitochondrion

Technical term

Reference proteome

Domain

Transit peptide

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