COMP Rabbit pAb (APR22914N)

CAT: 0882-APR22914N-01Size: 50 µLDry Ice: NoHazardous: No

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CAT#:0882-APR22914N-01Size:50 µL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Contraction or expansion of a 5 aa aspartate repeat and other mutations can cause pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED) .

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality COMP Rabbit pAb (APR22914N) .

Synonyms

COMP; EDM1; EPD1; MED; PSACH; THBS5; TSP5

Gene ID

1311

UniProt

P49747

Cellular Locus

Secreted, extracellular matrix, extracellular space

Dilution

WB 1:500 - 1:2000 IHC 1:50 - 1:200

Form

Liquid

Buffer

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Molecular Weight

Calculated MW: 77kDa/82kDa Observed MW: Refer to figures

Storage Conditions

Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Gene ID URL

https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1311

Uniprot URL

https://www.uniprot.org/uniprot/P49747

AA Sequence

GQGQSPLGSDLGPQMLRELQETNAALQDVRELLRQQVREITFLKNTVMECDACGMQQSVRTGLPSVRPLLHCAPGFCFPGVACIQTESGARCGPCPAGFTGNGSHCTDVNECNAHPCFPRVRCINTSPGFRCEACPPGYSG

UniProtKB · P49747

Cartilage oligomeric matrix protein

COMP_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P49747
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: COMP
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: COMP
EC number: —
Processing: Precursor
Secondary accessions: B4DKJ3, O14592, Q16388, Q16389, Q2NL86, Q8N4T2

Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

ApoptosisCell adhesion

Ligand

Calcium

Disease

Disease variantDwarfism

PTM

Disulfide bondGlycoprotein

Domain

EGF-like domainRepeatSignal

Cellular component

Extracellular matrixSecreted

Molecular function

Heparin-binding

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