SDHD Rabbit pAb (APR22834N)

CAT: 0882-APR22834N-01Size: 50 µLDry Ice: NoHazardous: No

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CAT#:0882-APR22834N-01Size:50 µL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

This gene encodes a member of complex II of the respiratory chain, which is responsible for the oxidation of succinate. The encoded protein is one of two integral membrane proteins anchoring the complex to the matrix side of the mitochondrial inner membrane. Mutations in this gene are associated with the formation of tumors, including hereditary paraganglioma. Transmission of disease occurs almost exclusively through the paternal allele, suggesting that this locus may be maternally imprinted. There are pseudogenes for this gene on chromosomes 1, 2, 3, 7, and 18. Alternative splicing results in multiple transcript variants.

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality SDHD Rabbit pAb (APR22833N0) .

Synonyms

SDHD; CBT1; CII-4; CWS3; PGL; PGL1; QPs3; SDH4; cybS

Gene ID

6392

UniProt

O14521

Cellular Locus

Mitochondrion inner membrane, Multi-pass membrane protein

Dilution

WB 1:500 - 1:2000

Form

Liquid

Buffer

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Molecular Weight

Calculated MW: 9kDa/12kDa/15kDa/17kDa Observed MW: 17kDa

Storage Conditions

Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Gene ID URL

https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6392

Uniprot URL

https://www.uniprot.org/uniprot/O14521

AA Sequence

HLSPSHHSGSKAASLHWTSERVVSVLLLGLLPAAYLNPCSAMDYSLAAALTLHGHWGLGQVVTDYVHGDALQKAAKAGLLALSALTFAGLCYFNYHDVGIC

UniProtKB · O14521

Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial

DHSD_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: O14521
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: SDHD
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: CybS
EC number: —
Processing: Precursor
Secondary accessions: A6ND90, B3KQQ8, E9PIC0, E9PIG3, E9PQI9, Q53XW5, Q6IRW2

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Disease

Disease variantPrimary mitochondrial disease

Biological process

Electron transportTransportTricarboxylic acid cycle

Ligand

HemeIronMetal-binding

Cellular component

MembraneMitochondrionMitochondrion inner membrane

Domain

Transit peptideTransmembraneTransmembrane helix

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