CRY1 Rabbit pAb (APR20239N)

CAT: 0882-APR20239N-01Size: 50 µLDry Ice: NoHazardous: No

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CAT#:0882-APR20239N-01Size:50 µL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Loss of the related gene in mouse results in a shortened circadian cycle in complete darkness.

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality CRY1 Rabbit pAb (APR20239N) .

Synonyms

CRY1; PHLL1; DSPD

Gene ID

1407

UniProt

Q16526

Cellular Locus

Cytoplasm, Nucleus

Dilution

WB 1:500 - 1:2000 IHC 1:50 - 1:200

Form

Liquid

Buffer

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Molecular Weight

Calculated MW: 66kDa Observed MW: 66kDa

Storage Conditions

Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Gene ID URL

https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1407

Uniprot URL

https://www.uniprot.org/uniprot/Q16526

AA Sequence

PNGNGGFMGYSAENIPGCSSSGSCSQGSGILHYAHGDSQQTHLLKQGRSSMGTGLSGGKRPSQEEDTQSIGPKVQRQSTN

UniProtKB · Q16526

Cryptochrome-1

CRY1_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: Q16526
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: CRY1
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: —
Secondary accessions: —

Protein keywords

Biological process

Biological rhythmsSensory transductionTranscriptionTranscription regulation

Ligand

ChromophoreFADFlavoproteinNucleotide-binding

Cellular component

CytoplasmNucleus

PTM

Isopeptide bondPhosphoproteinUbl conjugation

Molecular function

Photoreceptor proteinReceptorRepressor

Technical term

Proteomics identificationReference proteome

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Alternative Products

Catalog	Name
A13662-01	CRY1 Rabbit pAb
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