MCM4 Rabbit pAb (APR20102N)

CAT: 0882-APR20102N-01Size: 50 µLDry Ice: NoHazardous: No

1 / 1

CAT#:0882-APR20102N-01Size:50 µL

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Background

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported.

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality MCM4 Rabbit pAb (APR20102N) .

Synonyms

MCM4; CDC21; CDC54; NKCD; NKGCD; P1-CDC21; hCdc21

Gene ID

4173

UniProt

P33991

Cellular Locus

Nucleus

Dilution

WB 1:500 - 1:2000 IHC 1:100 - 1:200

Form

Liquid

Buffer

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Molecular Weight

Calculated MW: 96kDa Observed MW: 110kDa

Storage Conditions

Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Gene ID URL

https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4173

Uniprot URL

https://www.uniprot.org/uniprot/P33991

AA Sequence

QMIKLQESPEDMPAGQTPHTVILFAHNDLVDKVQPGDRVNVTGIYRAVPIRVNPRVSNVKSVYKTHIDVIHYRKTDAKRLHGLDEEAEQKLFSEKRVELLK

UniProtKB · P33991

DNA replication licensing factor MCM4

MCM4_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P33991
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: MCM4
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: 3.6.4.12
Processing: —
Secondary accessions: Q8NEH1, Q99658

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationIsopeptide bondPhosphoproteinUbl conjugation

Ligand

ATP-bindingNucleotide-binding

Biological process

Cell cycleDNA replication

Cellular component

ChromosomeNucleus

Molecular function

DNA-bindingHelicaseHydrolase

Related Products

Catalog	Name
APR25075N-01	MCM4 Rabbit pAb (APR25075N)
APR20103N-01	MCM5 Rabbit pAb (APR20103N)
AMR12100N-01	MCM4 Rabbit mAb (AMR12100N)
APR21102N-01	PDP1 Rabbit pAb (APR21102N)
APR20802N-01	RPL24 Rabbit pAb (APR20802N)
APR20302N-01	ST3GAL2 Rabbit pAb (APR20302N)
APR20172N-01	DNMT3L Rabbit pAb (APR20172N)
APR20162N-01	IGF2BP1 Rabbit pAb (APR20162N)
APR20152N-01	RANKL Rabbit pAb (APR20152N)
APR20142N-01	TPM3 Rabbit pAb (APR20142N)

Alternative Products

Catalog	Name
MBS9470916-01	MCM4 Rabbit mAb
E47R11298	MCM4 Rabbit pAb
GTR18220440-01	Rabbit MCM4 Antibody