BTK Rabbit pAb (APR19360N)

CAT: 0882-APR19360N-01Size: 50 µLDry Ice: NoHazardous: No

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CAT#:0882-APR19360N-01Size:50 µL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

The protein encoded by this gene plays a crucial role in B-cell development. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement. Alternative splicing results in multiple transcript variants encoding different isoforms.

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality BTK Rabbit pAb (APR19360N) .

Synonyms

AGMX1; AT; ATK; BPK; IMD1; PSCTK1; XLA; BTK

Gene ID

695

UniProt

Q06187

Cellular Locus

Cell membrane, Cytoplasm, Nucleus, Peripheral membrane protein

Dilution

WB 1:500 - 1:2000 IHC 1:50 - 1:200

Form

Liquid

Buffer

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Molecular Weight

Calculated MW: 76kDa/79kDa Observed MW: 76kDa

Storage Conditions

Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Gene ID URL

https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=695

Uniprot URL

https://www.uniprot.org/uniprot/Q06187

AA Sequence

GSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEA

UniProtKB · Q06187

Tyrosine-protein kinase BTK

BTK_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: Q06187
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: BTK
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: 2.7.10.2
Processing: —
Secondary accessions: B2RAW1, Q32ML5

Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationPhosphoprotein

Biological process

Adaptive immunityApoptosisImmunityInnate immunityTranscriptionTranscription regulation

Coding sequence diversity

Alternative promoter usage

Ligand

ATP-bindingLipid-bindingMetal-bindingNucleotide-bindingZinc

Cellular component

Cell membraneCytoplasmMembraneNucleus

Disease

Disease variantDwarfism

Molecular function

KinaseTransferaseTyrosine-protein kinase

Domain

SH2 domainSH3 domainZinc-finger

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