IL17A Rabbit pAb (APR19084N)

CAT: 0882-APR19084N-01Size: 50 µLDry Ice: NoHazardous: No

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CAT#:0882-APR19084N-01Size:50 µL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO) . High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality IL17A Rabbit pAb (APR19079N4) .

Synonyms

IL17A; CTLA-8; CTLA8; IL-17; IL-17A; IL17

Gene ID

3605

UniProt

Q16552

Cellular Locus

Secreted

Dilution

WB 1:500 - 1:2000 IHC 1:50 - 1:200

Form

Liquid

Buffer

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Molecular Weight

Calculated MW: 17kDa Observed MW: 15-25KDa

Storage Conditions

Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Gene ID URL

https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3605

Uniprot URL

https://www.uniprot.org/uniprot/Q16552

AA Sequence

GITIPRNPGCPNSEDKNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEILVLRREPPHCPNSFRLEKILVSVGCTCVTPIVHHVA

UniProtKB · Q16552

Interleukin-17A

IL17_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: Q16552
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: IL17A
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: IL-17, IL-17A
EC number: —
Processing: Precursor
Secondary accessions: Q5T2P0

Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Biological process

Adaptive immunityImmunityInflammatory responseInnate immunity

Molecular function

Cytokine

PTM

Disulfide bondGlycoprotein

Cellular component

Secreted

Domain

Signal

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