CD40 Rabbit pAb (APR17344N)

CAT: 0882-APR17344N-01Size: 50 µLDry Ice: NoHazardous: No

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CAT#:0882-APR17344N-01Size:50 µL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3) . Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality CD40 Rabbit pAb (APR17344N) .

Synonyms

CD40; Bp50; CDW40; TNFRSF5; p50

Gene ID

958

UniProt

P25942

Cellular Locus

Cell membrane, Secreted, Single-pass type I membrane protein

Applications

FC (Mus musculus) WB (Mauremys sinensis , Homo sapiens)

Dilution

WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200

Form

Liquid

Buffer

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Molecular Weight

Calculated MW: 22kDa/30kDa Observed MW: 45KDa

Storage Conditions

Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Gene ID URL

https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=958

Uniprot URL

https://www.uniprot.org/uniprot/P25942

AA Sequence

Email for sequence

UniProtKB · P25942

Tumor necrosis factor receptor superfamily member 5

TNR5_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P25942
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: CD40
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: Precursor
Secondary accessions: E1P5S9, Q53GN5, Q5JY15, Q5U007, Q7M4Q8, Q86YK5, Q9BYU0

Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneMembraneSecreted

Disease

Disease variant

PTM

Disulfide bondGlycoprotein

Biological process

Immunity

Molecular function

Receptor

Domain

RepeatSignalTransmembraneTransmembrane helix

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