COMT Rabbit mAb (AMR12366N)

CAT: 0882-AMR12366N-01Size: 50 µLDry Ice: NoHazardous: No

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CAT#:0882-AMR12366N-01Size:50 µL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT) . The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. [provided by RefSeq, Sep 2008]

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality COMT Rabbit mAb (AMR12366N) .

Synonyms

HEL-S-98n

Gene ID

1312

UniProt

P21964

Cellular Locus

Cell membrane, Cytoplasm, Extracellular side, Single-pass type II membrane protein

Dilution

WB 1:500 - 1:2000

Form

Liquid

Buffer

Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.

Molecular Weight

Calculated MW: 24,28kDa Observed MW: 25KDa/28KDa

Storage Conditions

Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Gene ID URL

https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1312

Uniprot URL

https://www.uniprot.org/uniprot/P21964

AA Sequence

Email for sequence

UniProtKB · P21964

Catechol O-methyltransferase

COMT_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P21964
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: COMT
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: 2.1.1.6
Processing: —
Secondary accessions: A8MPV9, Q6IB07, Q6ICE6, Q9BWC7

Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative initiation

Biological process

Catecholamine metabolismLipid metabolismNeurotransmitter degradation

Cellular component

Cell membraneCytoplasmMembrane

Ligand

MagnesiumMetal-bindingS-adenosyl-L-methionine

Molecular function

MethyltransferaseTransferase

PTM

Phosphoprotein

Disease

Schizophrenia

Domain

Signal-anchorTransmembraneTransmembrane helix

Related Products

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AMR12368N-01	Desmin Rabbit mAb (AMR12368N)
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AMR12636N-01	NQO2 Rabbit mAb (AMR12636N)
AMR12386N-01	PAX7 Rabbit mAb (AMR12386N)
AMR12367N-01	UBE2I Rabbit mAb (AMR12367N)
AMR12361N-01	SENP1 Rabbit mAb (AMR12361N)
AMR12336N-01	PAK2 Rabbit mAb (AMR12336N)
AMR11366N-01	PHD3 Rabbit mAb (AMR11366N)
AMR12766N-01	HRAS Rabbit mAb (AMR12766N)
AMR12356N-01	BMP6 Rabbit mAb (AMR12356N)

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