EIF3B Rabbit mAb (AMR12084N)

CAT: 0882-AMR12084N-01Size: 50 µLDry Ice: NoHazardous: No

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CAT#:0882-AMR12084N-01Size:50 µL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3 complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC. The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality eIF3B Rabbit mAb (AMR12084N) .

Synonyms

EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9; PRT1

Gene ID

8662

UniProt

P55884

Cellular Locus

Cytoplasm

Dilution

WB 1:500 - 1:2000 IF 1:50 - 1:200

Form

Liquid

Buffer

Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.

Molecular Weight

Calculated MW: 116kDa Observed MW: 116KDa

Storage Conditions

Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Gene ID URL

https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8662

Uniprot URL

https://www.uniprot.org/uniprot/P55884

AA Sequence

Email for sequence

UniProtKB · P55884

Eukaryotic translation initiation factor 3 subunit B

EIF3B_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P55884
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: EIF3B
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: eIF3b
EC number: —
Processing: —
Secondary accessions: A4D208, Q2NL77, Q9UMF9

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationPhosphoprotein

Coding sequence diversity

Alternative splicing

Cellular component

Cytoplasm

Molecular function

Initiation factorRNA-binding

Biological process

Protein biosynthesis

Domain

RepeatWD repeat

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