CLOCK Rabbit mAb (AMR11800N)

CAT: 0882-AMR11800N-01Size: 50 µLDry Ice: NoHazardous: No

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CAT#:0882-AMR11800N-01Size:50 µL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

The protein encoded by this gene plays a central role in the regulation of circadian rhythms. The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and contains DNA binding histone acetyltransferase activity. The encoded protein forms a heterodimer with ARNTL (BMAL1) that binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Polymorphisms in this gene may be associated with behavioral changes in certain populations and with obesity and metabolic syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality CLOCK Rabbit mAb (AMR11800N) .

Synonyms

KAT13D; bHLHe8

Gene ID

9575

UniProt

O15516

Cellular Locus

Cytoplasm, Nucleus

Dilution

WB 1:500 - 1:2000 IF 1:50 - 1:200

Form

Liquid

Buffer

Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.

Molecular Weight

Calculated MW: 95kDa Observed MW: 95kDa

Storage Conditions

Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Gene ID URL

https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9575

Uniprot URL

https://www.uniprot.org/uniprot/O15516

AA Sequence

Email for sequence

UniProtKB · O15516

Circadian locomoter output cycles protein kaput

CLOCK_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: O15516
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: CLOCK
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: hCLOCK
EC number: 2.3.1.48
Processing: —
Secondary accessions: A0AV01, A2I2N9, O14516, Q9UIT8

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Molecular function

ActivatorAcyltransferaseDNA-bindingTransferase

Biological process

Biological rhythmsDNA damageTranscriptionTranscription regulation

Cellular component

CytoplasmNucleus

PTM

Isopeptide bondPhosphoproteinUbl conjugation

Domain

Repeat

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