ALIX (PDCD6IP) Mouse Monoclonal Antibody [Clone ID: LBI1A4]

• Background:

  This gene encodes a protein that functions within the ESCRT pathway in the abscission stage of cytokinesis, in intralumenal endosomal vesicle formation, and in enveloped virus budding. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. Related pseudogenes have been identified on chromosome 15. [provided by RefSeq, Jan 2012]

• Synonyms:

  AIP1; ALIX; DRIP4; HP95

• Gene Name:

  Homo sapiens programmed cell death 6 interacting protein (PDCD6IP), transcript variant 1, mRNA.

• Gene ID:

  10015

• UniProt:

  Q8WUM4

• Conjugation:

  Unconjugated

• Related Pathways:

  Endocytosis

• Field of Research:

  Endocytosis

• Dilution:

  WB 1:4000, IHC 1:150

• Form:

  Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

• Buffer:

  Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

• Function:

  Druggable Genome

• Storage Conditions:

  Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

• Symbol:

  PDCD6IP

• Overview:

  Carrier-free (BSA/glycerol-free) PDCD6IP mouse monoclonal antibody, clone LBI1A4

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=10015

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q8WUM4