IL6R Mouse Monoclonal Antibody [Clone ID: LBI2F4]

• Background:

  This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9. [provided by RefSeq, May 2011]

• Synonyms:

  CD126; gp80; IL-6R-1; IL-6RA; IL6Q; IL6RA; IL6RQ

• Gene Name:

  Homo sapiens interleukin 6 receptor (IL6R), transcript variant 1, mRNA.

• Gene ID:

  3570

• UniProt:

  P08887

• Conjugation:

  Unconjugated

• Related Pathways:

  Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Jak-STAT signaling pathway

• Field of Research:

  Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Jak-STAT signaling pathway

• Dilution:

  WB 1:4000, IHC 1:150, IF 1:100

• Form:

  Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

• Buffer:

  Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

• Function:

  Druggable Genome, ES Cell Differentiation/IPS, Transmembrane

• Storage Conditions:

  Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

• Symbol:

  IL6R

• Overview:

  Carrier-free (BSA/glycerol-free) IL6R mouse monoclonal antibody, clone LBI2F4

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=3570

• Uniprot URL:

  https://www.uniprot.org/uniprot/P08887