IL6R (NM_181359) Human Recombinant Protein

• Background:

  This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been identified in this gene. A pseudogene of this gene is found on chromosome 9. [provided by RefSeq, Aug 2020]

• Synonyms:

  CD126; gp80; HIES5; IL-1Ra; IL-6R; IL-6R-1; IL-6RA; IL6Q; IL6QTL; IL6RA; IL6RQ

• Gene ID:

  3570

• UniProt:

  P08887

• Accession Number mRNA:

  NM_181359

• Chromosomal Location:

  1q21.3

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Jak-STAT signaling pathway

• Field of Research:

  Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Jak-STAT signaling pathway

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, ES Cell Differentiation/IPS, Transmembrane

• Molecular Weight:

  38.4 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  IL6R

• Species:

  Human

• Protein ID:

  NP_852004

• Overview:

  Recombinant protein of human interleukin 6 receptor (IL6R), transcript variant 2

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/3570

• Uniprot URL:

  https://www.uniprot.org/uniprot/P08887

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_181359

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_852004