TrkB (NTRK2) Mouse Monoclonal Antibody [Clone ID: LBI2E1]

• Background:

  This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternate transcriptional splice variants encoding different isoforms have been found for this gene

• Synonyms:

  GP145-TrkB; OBHD; trk-B; TRKB

• Gene Name:

  Homo sapiens neurotrophic receptor tyrosine kinase 2 (NTRK2), transcript variant b, mRNA.

• Gene ID:

  4915

• UniProt:

  Q16620

• Conjugation:

  Unconjugated

• Related Pathways:

  MAPK signaling pathway, Neurotrophin signaling pathway

• Field of Research:

  MAPK signaling pathway, Neurotrophin signaling pathway

• Dilution:

  WB 1:1000, IHC 1:150, IF 1:100

• Form:

  Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

• Buffer:

  Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

• Function:

  Druggable Genome, Protein Kinase, Transmembrane

• Storage Conditions:

  Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

• Symbol:

  NTRK2

• Overview:

  Carrier-free (BSA/glycerol-free) NTRK2 mouse monoclonal antibody, clone LBI2E1

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=4915

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q16620