TrkB (NTRK2) (NM_006180) Human Recombinant Protein

• Background:

  This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

• Synonyms:

  DEE58; EIEE58; GP145-TrkB; OBHD; trk-B; TRKB

• Gene ID:

  4915

• UniProt:

  Q16620, Q5VWE5, A0A024R230

• Accession Number mRNA:

  NM_006180

• Chromosomal Location:

  9q21.33

• Expression System:

  Sf9

• Tag:

  C-DDK

• Related Pathways:

  MAPK signaling pathway, Neurotrophin signaling pathway

• Field of Research:

  MAPK signaling pathway, Neurotrophin signaling pathway

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  50mM Tris-HCl, pH8.0, 100mM glycine, 10% glycerol.

• Function:

  Druggable Genome, Protein Kinase, Transmembrane

• Molecular Weight:

  44.2 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  NTRK2

• Species:

  Human

• Protein ID:

  NP_006171

• Overview:

  Recombinant protein of human neurotrophic tyrosine kinase, receptor, type 2 (NTRK2), transcript variant a, residues 32-430aa, with C-terminal DDK tag, expressed in sf9, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/4915

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q16620

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_006180

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_006171