Alpha Actinin (ACTN1) Mouse Monoclonal Antibody [Clone ID: LBI7A4]

• Background:

  Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments.

• Synonyms:

  BDPLT15

• Gene Name:

  Homo sapiens actinin alpha 1 (ACTN1), transcript variant 2, mRNA.

• Gene ID:

  87

• UniProt:

  P12814

• Conjugation:

  Unconjugated

• Related Pathways:

  Adherens junction, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Focal adhesion, Leukocyte transendothelial migration, Regulation of actin cytoskeleton, Systemic lupus erythematosus, Tight junction

• Field of Research:

  Adherens junction, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Focal adhesion, Leukocyte transendothelial migration, Regulation of actin cytoskeleton, Systemic lupus erythematosus, Tight junction

• Dilution:

  WB 1:2000, IHC 1:50, IF 1:100

• Form:

  Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

• Buffer:

  Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

• Function:

  Druggable Genome, ES Cell Differentiation/IPS

• Storage Conditions:

  Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

• Symbol:

  ACTN1

• Overview:

  Carrier-free (BSA/glycerol-free) alpha-actinin mouse monoclonal antibody, clone LBI7A4

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=87

• Uniprot URL:

  https://www.uniprot.org/uniprot/P12814