AMACR Mouse Monoclonal Antibody [Clone ID: UMLBI68]

• Background:

  This gene encodes a racemase. The encoded enzyme interconverts pristanoyl-CoA and C27-bile acylCoAs between their (R) - and (S) -stereoisomers. The conversion to the (S) -stereoisomers is necessary for degradation of these substrates by peroxisomal beta-oxidation. Encoded proteins from this locus localize to both mitochondria and peroxisomes. Mutations in this gene may be associated with adult-onset sensorimotor neuropathy, pigmentary retinopathy, and adrenomyeloneuropathy due to defects in bile acid synthesis. Alternatively spliced transcript variants have been described. Read-through transcription also exists between this gene and the upstream neighboring C1QTNF3 (C1q and tumor necrosis factor related protein 3) gene. [provided by RefSeq, Mar 2011]

• Synonyms:

  AMACRD; CBAS4; RACE; RM

• Gene Name:

  Homo sapiens alpha-methylacyl-CoA racemase (AMACR), transcript variant 1, mRNA.

• Gene ID:

  23600

• UniProt:

  Q9UHK6

• Conjugation:

  Unconjugated

• Related Pathways:

  Metabolic pathways, Primary bile acid biosynthesis

• Field of Research:

  Metabolic pathways, Primary bile acid biosynthesis

• Dilution:

  IHC 1:100

• Form:

  Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

• Buffer:

  Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

• Function:

  Druggable Genome

• Storage Conditions:

  Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

• Symbol:

  AMACR

• Overview:

  Carrier-free (BSA/glycerol-free) AMACR mouse monoclonal antibody, clone UMLBI68

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=23600

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9UHK6