AMACR Mouse Monoclonal Antibody [Clone ID: LBI2A11]

• Background:

  This gene encodes a racemase. The encoded enzyme interconverts pristanoyl-CoA and C27-bile acylCoAs between their (R) - and (S) -stereoisomers. The conversion to the (S) -stereoisomers is necessary for degradation of these substrates by peroxisomal beta-oxidation. Encoded proteins from this locus localize to both mitochondria and peroxisomes. Mutations in this gene may be associated with adult-onset sensorimotor neuropathy, pigmentary retinopathy, and adrenomyeloneuropathy due to defects in bile acid synthesis. Alternatively spliced transcript variants have been described. Read-through transcription also exists between this gene and the upstream neighboring C1QTNF3 (C1q and tumor necrosis factor related protein 3) gene. [provided by RefSeq, Mar 2011]

• Synonyms:

  AMACRD; CBAS4; RACE; RM

• Gene Name:

  Alpha-methylacyl-CoA racemase

• Gene ID:

  23600

• UniProt:

  Q9UHK6

• Conjugation:

  Unconjugated

• Related Pathways:

  Metabolic pathways, Primary bile acid biosynthesis

• Field of Research:

  Metabolic pathways, Primary bile acid biosynthesis

• Concentration:

  1 mg/ml

• Dilution:

  WB 1:2000, IHC 1:150

• Form:

  PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

• Buffer:

  PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

• Function:

  Druggable Genome

• Storage Conditions:

  Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

• Symbol:

  AMACR

• Overview:

  AMACR mouse monoclonal antibody, clone LBI2A11

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=23600

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9UHK6