IL10 Mouse Monoclonal Antibody [Clone ID: LBI9H3]

• Background:

  The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. [provided by RefSeq, May 2011]

• Synonyms:

  CSIF; GVHDS; IL-10; IL10A; TGIF

• Gene Name:

  Interleukin 10

• Gene ID:

  3586

• UniProt:

  P22301

• Conjugation:

  Unconjugated

• Related Pathways:

  Allograft rejection, Asthma, Autoimmune thyroid disease, Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway

• Field of Research:

  Allograft rejection, Asthma, Autoimmune thyroid disease, Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway

• Concentration:

  1 mg/ml

• Dilution:

  WB 1:500

• Form:

  PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

• Buffer:

  PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

• Function:

  Druggable Genome, ES Cell Differentiation/IPS, Secreted Protein

• Storage Conditions:

  Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

• Symbol:

  IL10

• Overview:

  IL10 mouse monoclonal antibody, clone LBI9H3

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=3586

• Uniprot URL:

  https://www.uniprot.org/uniprot/P22301