IL1RAP Antibody (Center) [APR33614G]

• Background:

  Tissue Location: Detected in liver, skin, placenta, thymus and lung. Isoform 4 is predominantly expressed in brain. Overexpressed on candidate chronic myeloid leukemia (CML) stem cells, hematopoietic stem cells and mononuclear cells of patients with acute myeloid leukemia (AML) . Overexpressed in patients with chronic obstructive pulmonary disease (COPD) . Expressed in T-helper 1 (Th1) and T-helper 2 (Th2) cell subsets (PubMed:10653850) .

• Synonyms:

  Interleukin-1 receptor accessory protein, IL-1 receptor accessory protein, IL-1RAcP, Interleukin-1 receptor 3, IL-1R-3, IL-1R3, IL1RAP, C3orf13, IL1R3

• Gene Name:

  IL1RAP

• Gene ID:

  3556

• UniProt:

  Q9NPH3

• Chromosomal Location:

  [Isoform 1]: Cell membrane; Single-pass type I membrane protein [Isoform 3]: Secreted.

• Applications:

  WB, FC, IHC-P

• Dilution:

  IHC-P--1:100~500 WB--1:2000 FC--1:25

• Form:

  Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

• Function:

  Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity) . Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Coreceptor for IL1RL1 in the IL-33 signaling system. Can bidirectionally induce pre- and postsynaptic differentiation of neurons by trans-synaptically binding to PTPRD (By similarity) . May play a role in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (Probable) .

• Molecular Weight:

  65418

• Storage Conditions:

  Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

• Overview:

  We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality IL1RAP Antibody (Center) [APR33614G].

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=3556

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9NPH3