ITGA2B (Integrin alpha-IIb heavy chain) Antibody (C-term) [APR33284G]

• Background:

  Tissue Location: Isoform 1 and isoform 2 are expressed in platelets and megakaryocytes, but not in reticulocytes. Not detected in Jurkat, nor in U937 cell lines (PubMed:2351656) . Isoform 3 is expressed in prostate adenocarcinoma, as well as in several erythroleukemia, prostate adenocarcinoma and melanoma cell lines, including PC-3, DU- 145, HEL, WM983A, WM983B and WM35. Not detected in platelets, nor in normal prostate (at protein level) (PubMed:9809974)

• Synonyms:

  Integrin alpha-IIb, GPalpha IIb, GPIIb, Platelet membrane glycoprotein IIb, CD41, Integrin alpha-IIb heavy chain, Integrin alpha-IIb light chain, form 1, Integrin alpha-IIb light chain, form 2, ITGA2B, GP2B, ITGAB

• Gene Name:

  ITGA2B

• Gene ID:

  3674

• UniProt:

  P08514

• Chromosomal Location:

  Membrane; Single-pass type I membrane protein.

• Applications:

  WB

• Dilution:

  WB--1:2000

• Function:

  Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.

• Molecular Weight:

  113377

• Storage Conditions:

  Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

• Overview:

  We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality ITGA2B (Integrin alpha-IIb heavy chain) Antibody (C-term) [APR33284G].

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=3674

• Uniprot URL:

  https://www.uniprot.org/uniprot/P08514