Mouse Rad9a Antibody (C-term) [APR33102G]

• Background:

  Tissue Location: Expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis.

• Synonyms:

  Cell cycle checkpoint control protein RAD9A, mRAD9, DNA repair exonuclease rad9 homolog A, Rad9-like protein, Rad9a, Rad9

• Gene Name:

  Rad9a

• Gene ID:

  19367

• UniProt:

  Q9Z0F6

• Chromosomal Location:

  Nucleus.

• Applications:

  WB

• Dilution:

  WB--1:2000 WB--1:1000

• Function:

  Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER) . The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. RAD9A possesses 3'->5' double stranded DNA exonuclease activity (By similarity) .

• Molecular Weight:

  42059

• Storage Conditions:

  Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

• Overview:

  We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Mouse Rad9a Antibody (C-term) [APR33102G].

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=19367

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9Z0F6