TBCD7 Antibody (Center) [APR32751G]

• Background:

  Tissue Location: Highly expressed in heart, and slightly in kidney, liver and placenta.

• Synonyms:

  TBC1 domain family member 7, Cell migration-inducing protein 23, TBC1D7, TBC7

• Gene Name:

  TBC1D7

• Gene ID:

  107080638;51256

• UniProt:

  Q9P0N9

• Chromosomal Location:

  Cytoplasmic vesicle. Note=Localizes in the cytoplasmic vesicles of the endomembrane in association with TSC1-TSC2 complex

• Applications:

  WB

• Dilution:

  WB--1:1000

• Form:

  Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

• Function:

  Component of the TSC-TBC complex, that contains TBC1D7 in addition to the TSC1-TSC2 complex and consists of the functional complex possessing GTPase-activating protein (GAP) activity toward RHEB in response to alterations in specific cellular growth conditions. The small GTPase RHEB is a direct activator of the protein kinase activity of mTORC1 and the TSC-TBC complex acts as a negative regulator of mTORC1 signaling cascade by acting as a GAP for RHEB. Participates in the proper sensing of growth factors and glucose, but not amino acids, by mTORC1. It is unclear whether TBC1D7 acts as a GTPase-activating protein and additional studies are required to answer this question.

• Molecular Weight:

  33972

• Storage Conditions:

  Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

• Overview:

  We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality TBCD7 Antibody (Center) [APR32751G].

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=107080638;51256

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9P0N9