COMP Antibody (Center) [APR32352G]

• Background:

  Tissue Location: Abundantly expressed in the chondrocyte extracellular matrix, and is also found in bone, tendon, ligament and synovium and blood vessels. Increased amounts are produced during late stages of osteoarthritis in the area adjacent to the main defect

• Synonyms:

  Cartilage oligomeric matrix protein, COMP, Thrombospondin-5, TSP5, COMP

• Gene Name:

  COMP

• Gene ID:

  1311

• UniProt:

  P49747

• Chromosomal Location:

  Secreted, extracellular space, extracellular matrix

• Applications:

  IHC-P, WB, FC

• Dilution:

  WB--1:1000 IHC-P--1:100~500 FC--1:10~50

• Form:

  Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

• Function:

  May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP) . Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7 (By similarity) .

• Molecular Weight:

  82860

• Storage Conditions:

  Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

• Overview:

  We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality COMP Antibody (Center) [APR32352G].

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=1311

• Uniprot URL:

  https://www.uniprot.org/uniprot/P49747