TRIM22 Antibody (N-term) [APR31847G]

• Background:

  Tissue Location: Strongly expressed in peripheral blood leukocytes, spleen, thymus, and ovary. Expressed at basal levels in other tissues

• Synonyms:

  E3 ubiquitin-protein ligase TRIM22, 632-, 50 kDa-stimulated trans-acting factor, RING finger protein 94, Staf-50, Tripartite motif-containing protein 22, TRIM22, RNF94, STAF50

• Gene Name:

  TRIM22

• Gene ID:

  10346

• UniProt:

  Q8IYM9

• Chromosomal Location:

  Cytoplasm. Nucleus. Nucleus speckle. Nucleus, Cajal body Note=Localizes predominantly to the nucleus, found in cytoplasm to some extent. Forms distinct nuclear bodies that undergo dynamic changes during cell cycle progression. Nuclear bodies start to form in the early G0/G1 phase but become speckle-like in the S-phase and completely dispersed in mitosis. 35% of TRIM22 nuclear bodies overlap or are found adjacent to Cajal bodies

• Applications:

  WB

• Dilution:

  WB--1:1000

• Form:

  Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

• Function:

  Interferon-induced antiviral protein involved in cell innate immunity. The antiviral activity could in part be mediated by TRIM22- dependent ubiquitination of viral proteins. Plays a role in restricting the replication of HIV-1, encephalomyocarditis virus (EMCV) and hepatitis B virus (HBV) . Acts as a transcriptional repressor of HBV core promoter. May have E3 ubiquitin-protein ligase activity.

• Molecular Weight:

  56947

• Storage Conditions:

  Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

• Overview:

  We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality TRIM22 Antibody (N-term) [APR31847G].

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=10346

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q8IYM9