TFEC Antibody (Center) [APR31841G]

• Background:

  Tissue Location: Expressed moderately in spleen, kidney, bone marrow, small intestine and leukocytes. Expressed weakly in testis, trachea and colon.

• Synonyms:

  Transcription factor EC, TFE-C, Class E basic helix-loop-helix protein 34, bHLHe34, Transcription factor EC-like, hTFEC-L, TFEC, BHLHE34, TCFEC, TFECL

• Gene Name:

  TFEC

• Gene ID:

  22797

• UniProt:

  O14948

• Chromosomal Location:

  Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:11467950}

• Applications:

  WB

• Dilution:

  WB--1:1000

• Form:

  Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

• Function:

  Transcriptional regulator that acts as a repressor or an activator. Acts as a transcriptional repressor on minimal promoter containing element F (that includes an E-box sequence) . Binds to element F in an E-box sequence-specific manner. Acts as a transcriptional transactivator on the proximal promoter region of the tartrate-resistant acid phosphatase (TRAP) E-box containing promoter (By similarity) . Collaborates with MITF in target gene activation (By similarity) . Acts as a transcriptional repressor on minimal promoter containing mu E3 enhancer sequence (By similarity) . Binds to mu E3 DNA sequence of the immunoglobulin heavy-chain gene enhancer (By similarity) . Binds DNA in a homo- or heterodimeric form.

• Molecular Weight:

  38788

• Storage Conditions:

  Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

• Overview:

  We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality TFEC Antibody (Center) [APR31841G].

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=22797

• Uniprot URL:

  https://www.uniprot.org/uniprot/O14948