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TGF-alpha Protein, Human, Recombinant

CAT: 0882-PH52302E0-01Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0882-PH52302E0-01Size:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The miR-137 served as a tumor suppressor in non-small cell lung cancer (NSCLC) and its suppressive effect is mediated by repressing TGFA expression. TGFA gene expression was significantly higher in tumor tissues compared to adjacent normal tissue and high TGFA gene expression strongly correlated with poor survival in patients with lung adenocarcinoma, and miR-374a suppresses lung adenocarcinoma cell proliferation and invasion via targeting TGFA gene expression. Transforming growth factor alpha (TGFA) is a well-characterized mammalian growth factor that might contribute to the development of Cleft lip and palate (CL/P) .
Overview
A DNA sequence encoding the human TGFa (P01135-1) (Val40-Ala89) was expressed and purified.
Synonyms
TFGA Protein, Human; TGFa Protein, Human
Gene Name
Transforming growth factor alpha
UniProt
P01135-1
Expression System
E. coli
Tag
No tag
Endotoxin
Please contact us for more information.
Purity
> 90 % as determined by SDS-PAGE.
Activity
1.Measured by its binding ability in a functional ELISA. Immobilized Human TGF-alpha (Cat:PH52302E0) at 2 μg/ml (100 μl/well) can bind Human EGFR hFc (Cat:PH50487M4), the ECof Human EGFR hFc is 80-500 ng/mL. 2. Measured in a cell proliferation assay using Balb/c 3T3 mouse embryonic fibroblast cells. The EDfor this effect is 0.5-2.5 ng/mL.
Form
Lyophilized
Buffer
Lyophilized from sterile 50 mM Tris, 100 mM NaCl, pH 8.0. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
Function
Cytokine Proteins, Biological Target proteins, Biomarker Proteins, Diagnostic proteins, Growth Factor proteins, Cell Therapy proteins
Molecular Weight
The recombinant human TGFa consists of 50 amino acids and has a predicted molecular mass of 5.6 kDa. The apparent molecular mass of it is approximately 13 kDa in SDS-PAGE under reducing conditions.
Storage Conditions
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
TGFA
Species
Human
Uniprot URL
https://www.uniprot.org/uniprot/P01135-1
AA Sequence
Val40-Ala89

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