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FGF8 Protein, Human, Recombinant

CAT: 0882-PH52196E0-01Size: 50 µgDry Ice: NoHazardous: No
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CAT#:0882-PH52196E0-01Size:50 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
In mammalian embryos, transient Fgf8 expression defines the developing isthmic region, lying between the midbrain and the first rhombomere, but there has been uncertainty about the existence of a distinct isthmic segment in postnatal mammals. Retinoic acid (RA) directly represses Fgf8 through a RARE-mediated mechanism that promotes repressive chromatin, thus providing valuable insight into the mechanism of RA-FGF antagonism during progenitor cell differentiation. Fgf8 encodes a key signaling factor, and its precise regulation is essential for embryo patterning.
Overview
A DNA sequence encoding the human FGF8a (NP_149355.1) (Gln23-Arg204) was expressed with an initial Met.
Synonyms
AIGF Protein, Human; FGF-8 Protein, Human; HBGF-8 Protein, Human; HH6 Protein, Human; KAL6 Protein, Human; NEWENTRY Protein, Human
Gene Name
Fibroblast growth factor 8 (androgen-induced)
Expression System
E. coli
Tag
No tag
Endotoxin
Please contact us for more information.
Purity
> 95 % as determined by SDS-PAGE.
Activity
Measured in a cell proliferation assay using BALB/c 3T3 mouse fibroblasts. The EDfor this effect is typically 0.8-3.3 μg/mL.
Form
Lyophilized
Buffer
Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH 8.5. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
Function
Cytokine Proteins, Growth Factor proteins, Biological Target proteins
Molecular Weight
The recombinant human FGF8a consists of 183 amino acids and predicts a molecular mass of 21.3 kDa.
Storage Conditions
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Fgf8
Species
Human
Protein ID
NP_149355.1
AA Sequence
Gln23-Arg204
Protein ID Link
https://www.ncbi.nlm.nih.gov/protein/NP_149355.1

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