Products for Research Use Only
RegisterLogin

CTRL Protein, Human, Recombinant (His Tag)

CAT: 0882-PH51956M2Size: 100 µgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0882-PH51956M2Size:100 µg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
CTRL-1, also known as chymotrypsin-like protease, belongs to thepeptidase S1 family. CTRL-1 contains 1peptidase S1 domain. Its expression is increased in preeclampsia (PE) . Placental-derived chymotrypsin-like protease is responsible for inducing endothelial inflammatory phenotypic changes possibly by upregulation of cell adhesion molecule expressions, activation of cellular protease, and induction of extracellular regulated kinase phosphorylation. Activated microglia have been observed in various neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis, and multiple sclerosis. Five structurally distinct inhibitors that are known to inhibit chymotrypsin-like proteases were partially protective. They might represent a novel class of drugs with benefit in diseases where overactivity of microglia contributes to the pathogenesis.
Overview
A DNA sequence encoding the human CTRL (P40313) (Met1-Asn264) was expressed with a polyhistidine tag at the C-terminus.
Synonyms
CTRL1 Protein, Human
Gene Name
Chymotrypsin-like
UniProt
P40313
Expression System
HEK293 Cells
Tag
C-His
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by SDS-PAGE.
Activity
At Leading Biology, the biological activity of a recombinant protein is routinely measured using a bioassay, e.g. chemotaxis or cell proliferation assay, enzyme assay, or a functional ELISA. When a recombinant protein is an enzyme, specific activity is derived from an enzymatic assay. Each enzyme is tested for potency by cleavage of a substrate. We are in the process of updating the biological activity data. If you have any questions regarding this update, please feel free to contact our technical support team.
Form
Lyophilized
Buffer
Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
Molecular Weight
The recombinant human CTRL consists of 257 amino acids and predicts a molecular mass of 27.6 KDa. It migrates as an approximately 35 and 32KDa band in SDS-PAGE under reducing conditions.
Storage Conditions
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
CTRL
Species
Human
Uniprot URL
https://www.uniprot.org/uniprot/P40313
AA Sequence
Met1-Asn264

UniProtKB · P40313

Chymotrypsin-like protease CTRL-1

CTRL_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P40313
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CTRL
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.4.21.-
Processing
Precursor
Secondary accessions
—
Protein keywords

PTM

Disulfide bondGlycoproteinZymogen

Molecular function

HydrolaseProteaseSerine protease

Technical term

Proteomics identificationReference proteome

Domain

Signal

Related Products

CatalogName
PM47765M5Ctrl (NM_023182) Mouse Recombinant Protein
PH37813M5Chymotrypsin like protease (CTRL) (NM_001907) Human Recombinant Protein
PH52607I2FTCD Protein, Human, Recombinant (His Tag)
PH52604M2-01Lilra6 Protein, Human, Recombinant (His Tag)
PH52588M2-01ULBP4 Protein, Human, Recombinant (His Tag)
PH52570M2Tapasin Protein, Human, Recombinant (His Tag)
PH52564M2NETO1 Protein, Human, Recombinant (His Tag)
PH52562M2CD300C Protein, Human, Recombinant (His Tag)
PH52559M2-01IL3 Protein, Human, Recombinant (His Tag)
PH52547M2RPE Protein, Human, Recombinant (His Tag)

Alternative Products

CatalogName
KMP1794Recombinant Human ACE2 Protein with His tag, His Tag
E40KMP1851Recombinant Human CD19 Protein with His tag, His Tag
E40KMP1859Recombinant Human CD47 Protein with His tag, His Tag
E40KMH915Recombinant Human CPNE1 Protein, His Tag & His Tag
E40KMP1872Recombinant Human GDNF Protein with His tag, His Tag
KMH126-01Recombinant Human IL14/TXLNA Protein, His Tag and His Tag
E40KMP1875Recombinant Human Flt-3 Protein with His tag, His Tag
E40KMP1861Recombinant Human DPP4/CD26 Protein with His tag, His Tag
E40KMH1801Recombinant Human Thrombopoietin/TPO Protein, His Tag & His Tag
E40KMP1878Recombinant Human IL-21 Protein with His tag, His Tag

Popular Products