IL11 Protein, Human, Recombinant

• Background:

  IL11 is a multifunctional cytokine first isolated in 199 from bone marrow-derived stromal cells. It is a key regulator of multiple events in hematopoiesis, most notably the stimulation of megakaryocyte maturation. IL11 is also known under the names adipogenesis inhibitory factor (AGIF) and oprelvekin. IL11 can improve platelet recovery after chemotherapy-induced thrombocytopenia, induce acute-phase proteins, modulate antigen-antibody responses, participate in the regulation of bone cell proliferation and differentiation, and could be used as a therapeutic for osteoporosis. IL11 stimulates the growth of certain lymphocytes and, in the murine model, stimulates an increase in the cortical thickness and strength of long bones. As a signaling molecule, IL11 has a variety of functions associated with its receptor interleukin 11 receptor alpha; such functions include placentation and to some extent of decidualization.

• Synonyms:

  AGIF Protein, Human; IL-11 Protein, Human

• Gene Name:

  Interleukin 11

• Expression System:

  E. coli

• Tag:

  No tag

• Endotoxin:

  Please contact us for more information.

• Purity:

  > 90 % as determined by SDS-PAGE.

• Activity:

  Measured in a cell proliferation assay using T1165 mouse plasmacytoma cells. The EDfor this effect is typically 1-8 ng/mL.

• Form:

  Lyophilized

• Buffer:

  Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.

• Function:

  Cytokine Proteins, Growth Factor proteins, Immunotherapy proteins, Interleukin proteins, Biological Target proteins, Cell Therapy proteins

• Molecular Weight:

  The recombinant human IL11 consists of 178 amino acids and predicts a molecular mass of 19.1 KDa. It migrates as an approximately 23 KDa band in SDS-PAGE under reducing conditions.

• Storage Conditions:

  In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  IL11

• Species:

  Human

• Protein ID:

  AAH12506.1

• Overview:

  A DNA sequence encoding the mature form of human IL11 (AAH12506.1) (Pro22-Leu199) was expressed.

• AA Sequence:

  Pro22-Leu199

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/protein/AAH12506.1