Products for Research Use Only
RegisterLogin

PR-Set7 Protein, Human, Recombinant

CAT: 0882-PH51573E0Size: 100 µgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0882-PH51573E0Size:100 µg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
KMT5A (known as PR-Set7/9, SETD8 and SET8), a member of the SET domain containing methyltransferase family specifically targeting H4K20 for methylation, has been implicated in multiple biological processes. Inhibition of KMT5A attenuated proliferation and induced apoptosis. Elevated KMT5A expression was significantly correlated with extrathyroidal extension, lymph node metastasis and advanced pathological stage of papillary thyroid cancer. KMT5A may be a novel oncogenic factor, specifically a regulator for lipid metabolism in papillary thyroid carcinoma.
Overview
A DNA sequence encoding the human SETD8 (NP_065115.3) (Lys 195-His 352) was expressed and purified, with two additional amino acids (Gly & Pro) at the N-terminus.
Synonyms
KMT5A Protein, Human; PR-Set7 Protein, Human; SET07 Protein, Human; SET8 Protein, Human
Gene Name
SET domain containing (lysine methyltransferase) 8
Expression System
E. coli
Tag
No tag
Endotoxin
Please contact us for more information.
Purity
> 98 % as determined by SDS-PAGE.
Activity
At Leading Biology, the biological activity of a recombinant protein is routinely measured using a bioassay, e.g. chemotaxis or cell proliferation assay, enzyme assay, or a functional ELISA. When a recombinant protein is an enzyme, specific activity is derived from an enzymatic assay. Each enzyme is tested for potency by cleavage of a substrate. We are in the process of updating the biological activity data. If you have any questions regarding this update, please feel free to contact our technical support team.
Form
Lyophilized
Buffer
Lyophilized from sterile 20mM Tris, 100mM NaCl, pH 8.0 Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
Function
Epigenetic proteins
Molecular Weight
The recombinant human SETD8 comprises 160 amino acids and has a predicted molecular mass of 18.2 kDa. It migrates as an approximately 18 kDa band in SDS-PAGE under reducing conditions as predicted.
Storage Conditions
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
KMT5A
Species
Human
Protein ID
NP_065115.3
AA Sequence
Lys195-His352
Protein ID Link
https://www.ncbi.nlm.nih.gov/protein/NP_065115.3

Related Products

CatalogName
APR30871G-01SET7 (SET9) Antibody (Center) [APR30871G]
PH34974M5SETD7 (NM_030648) Human Recombinant Protein
PH38423M5SET (NM_003011) Human Recombinant Protein
PH32833M5Senataxin (SETX) (NM_015046) Human Recombinant Protein
PH51105E1SETD7 Protein, Human, Recombinant (His Tag)
PH52164E0Pin1 Protein, Human, Recombinant
PH52156E0METTL11A Protein, Human, Recombinant
PH52087M0Mer Protein, Human, Recombinant
PH52085M0PILRA Protein, Human, Recombinant
PH52014M0BACE1 Protein, Human, Recombinant

Alternative Products

CatalogName
TMPY-01584-01PR-Set7 Protein, Human, Recombinant
PKSH031024Recombinant Human SETD8/PR-Set7 Protein
MBS2545689-01Recombinant Human SETD8 / PR-Set7 Protein
P518314SETD8/PR-Set7 Protein (Human)
046594SETD8/PR-Set7, Recombinant, Human discontinued
MBS7610941-01Recombinant Human SET7
PROTQ8WTS6-01Human SET7/9 Recombinant Protein
GTR18888924-01Human SET7 protein
ALX-201-178-C100SET7/9 (human), (recombinant)
ARP3896-01Recombinant Human SET7/9 Histone methyltransferase Protein

Popular Products