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FGF10 Protein, Human, Recombinant

CAT: 0882-PH51089E0-01Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0882-PH51089E0-01Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Fibroblast growth factor 10 (FGF10) is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF10 exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. FGF10 plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. FGF10 is required for normal branching morphogenesis. It may play a role in wound healing. Defects in FGF10 are the cause of autosomal dominant aplasia of lacrimal and salivary glands (ALSG) . ALSG has variable expressivity, and affected individuals may have aplasia or hypoplasia of the lacrimal, parotid, submandibular and sublingual glands and absence of the lacrimal puncta. The disorder is characterized by irritable eyes, recurrent eye infections, epiphora (constant tearing) and xerostomia (dryness of the mouth), which increases the risk of dental erosion, dental caries, periodontal disease and oral infections.
Overview
A DNA sequence encoding the mature form of human FGF10 (NP_004456.1) (Gln38-Ser208) was expressed.
Synonyms
KGF2 Protein, Human
Gene Name
Fibroblast growth factor 10
Expression System
E. coli
Tag
No tag
Endotoxin
Please contact us for more information.
Purity
> 95 % as determined by SDS-PAGE.
Activity
Measured in a cell proliferation assay using BaF3 mouse pro--B cells transfected with human FGFR2b. The ECfor this effect is typically 2-14 ng/mL.
Form
Lyophilized
Buffer
Lyophilized from sterile PBS, 1mM DTT, pH7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
Function
Cell Therapy proteins, Cytokine Proteins, Growth Factor proteins, Biological Target proteins
Molecular Weight
The recombinant human FGF10 consists of 172 amino acids and has a predicted molecular mass of 19.5 kDa as estimated in SDS-PAGE under reducing conditions.
Storage Conditions
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
FGF10
Species
Human
Protein ID
NP_004456.1
AA Sequence
Gln38-Ser208
Protein ID Link
https://www.ncbi.nlm.nih.gov/protein/NP_004456.1

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