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IL-5 Protein, Human, Recombinant

CAT: 0882-PH50897E0-01Size: 5 µgDry Ice: NoHazardous: No
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CAT#:0882-PH50897E0-01Size:5 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Interleukin 5 (IL-5) is a member of the interleukin family with a length of 115 amino acids. Interleukins are a group of cytokines (secreted proteins/signaling molecules) that were first seen to be expressed by white blood cells (leukocytes) and has been found in a wide variety of body cells. Interleukin 5 or IL-5 is produced by T helper-2 cells and mast cells. It helps to stimulate B cell growth and increase immunoglobulin secretion and is considered a key mediator in eosinophil activation. Interleukin 5 (IL-5) has long been associated with several allergic diseases, including allergic rhinitis and asthma. Growth in the number of circulating, airway tissue, and induced sputum eosinophils have been observed in patients with these diseases. IL-5 also had something with the terminally differentiated granulocyte eosinophils. IL-5 was originally found as an eosinophil colony-stimulating factor. It has been proved to be a major regulator of eosinophil accumulation in tissues and can modulate eosinophil behavior at every stage from maturation to survival.
Overview
A DNA sequence encoding the human IL5 (P05113) (Ile20-Ser134) was expressed.
Synonyms
EDF Protein, Human; IL-5 Protein, Human; Interleukin 5 Protein, Human; TRF Protein, Human
Gene Name
Interleukin 5
UniProt
P05113
Expression System
E. coli
Tag
No tag
Endotoxin
Please contact us for more information.
Purity
> 95 % as determined by SDS-PAGE.
Activity
Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. The EDfor this effect is typically 0.1-0.5 ng/mL.
Form
Lyophilized
Buffer
Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
Function
Biological Target proteins, Cytokine Proteins, Growth Factor proteins, Immunotherapy proteins, Interleukin proteins
Molecular Weight
The recombinant human IL5 consists of 115 amino acids and predicts a molecular mass of 13.1 KDa.
Storage Conditions
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
IL5
Species
Human
Uniprot URL
https://www.uniprot.org/uniprot/P05113
AA Sequence
Ile20-Ser134

UniProtKB · P05113

Interleukin-5

IL5_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P05113
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
IL5
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
IL-5
EC number
—
Processing
Precursor
Secondary accessions
Q13840
Protein keywords

Technical term

3D-structureDirect protein sequencingReference proteome

Coding sequence diversity

Alternative splicing

Molecular function

CytokineGrowth factor

PTM

Disulfide bondGlycoprotein

Cellular component

Secreted

Domain

Signal

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